Endocrine Abstracts

Vascular calcification is a regulated process with similarities to osteogenesis, however, the precise mechanism underlying this process is poorly understood. Pericytes are pluripotential microvascular cells which have been shown to differentiate along an osteogenic lineage. Glucocorticoids are widely prescribed drugs but have adverse side-effects including both vascular lesion formation and bone loss. The mechanism underpinning the contrasting effects of dexamethasone (dex) on...

Introduction: Thyroid hormones (TH) are essential regulators of metabolism and increase energy expenditure (EE). Mitochondria-rich brown adipose tissue (BAT) is specialised in thermogenesis and significantly contributes to EE. BAT contains essential components of TH action but TH transporters like MCT8 have not been characterised so far. As direct effects on O2 consumption and mitochondrial action have not been investigated before we tested MCT8 expression and direct effects o...

Introduction: Continuous Subcutaneous Insulin Infusion (CSII) has several advantages over Multiple Daily Injections (MDI) including better hourly delivery and avoidance of injections. However usage of CSII is significantly less in Cystic Fibrosis Related Diabetes (CFRD) compared to type 1 diabetes and published literature on use of CSII in children and adolescents with CFRD is minimal.We report two cases where CSII was used in CFRD resulting in a lower T...